Pushing the boundaries of proteomics: Orbitrap Astral mass spectrometer arrives at the Faculty of Life Sciences

What is Mass spectrometry?

Mass spectrometry is an analytical technique used to identify, characterize, and quantify molecules by measuring the mass-to-charge ratio and abundance of ions. It is essential for proteomics, metabolomics, and biomarker discovery, enabling the study of proteins, cellular processes, and biological markers. This advanced technology allows scientists of various disciplines to explore disease mechanisms, track molecular changes within cells, study climate change, oceanography, and microorganisms, or develop targeted therapies.

What makes the Orbitrap Astral mass spectrometer a game changer in scientific research?

The Thermo Scientific™ Orbitrap™ Astral™ mass spectrometer is a game-changer in mass spectrometry, featuring a revolutionary new mass analyzer. By integrating three mass analyzers to process multiple ion packages simultaneously, it sets a new gold standard for sensitivity, speed, dynamic range, resolution, and versatility. It delivers unprecedented throughput and deep proteome coverage, identifying over 10,000 proteins in a single-shot experiment. The system provides highly accurate, precise quantitation for both label-free and labeled techniques, including TMT, and excels at detecting thousands of proteins from even the tiniest samples, such as a single cell.

"We are thrilled to develop and integrate new workflows, methodologies, and techniques into the Orbitrap-Astral for our proteomic and protein-based applications, enabling us to flexibly address complex scientific questions. This presents a unique opportunity to showcase the transformative power of cutting-edge technology and innovation, seamlessly integrating them with life sciences to advance and drive scientific excellence", explains DDr Leila Afjehi, Head of Core Facility

With over 100 research publications utilizing the Thermo Scientific™ Orbitrap™ Astral™ mass spectrometer within less than two years of its commercialization, this technology has proven to be an exciting tool for advancing scientific research. These studies span a wide range of disciplines, demonstrating its versatility and profound impact on advancing knowledge and innovation. We invite our academic community and research partners to explore the new possibilities offered by this technology and to work with us to push the boundaries of scientific excellence.